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31	Material and Applied Chemistry	ABS-46
Psycho-Mechanic Characteristics of Bioplastic Composite from Glutinous Rice Flour Reinforced with Bamboo Leaf Powder Uma Fadzilia Arifin (a*), Nais Pinta Adetya (b), Wisnu Pambudi (a) a) Departement of Plastics and Rubber Processing Technology, Politeknik ATK Yogyakarta *umafadzilia[at]gmail.com b) Departement of Leather Processing Technolog,y Politeknik ATK Yogyakarta Abstract Plastic offers a variety of superior properties. Hence, they are widely used in various aspects of life. However, several plastics are not easy to recycle and be decomposed by the activities of organisms. They contribute negative impact on the environment and human health. Bioplastic can be alternative solution as biodegradable and safe plastics for health. The aim of this study was to evaluate psycho-mechanic characteristics of bioplastic composite glutinous rice flour reinforced bamboo leaf powder by considering the best composition. The glutinous rice flour containing high amylopectin acts as a matrix in bioplastic production. While bamboo leaf powder is a source of bio-silica used as filler. In this research, bioplastic synthesis process was carried out with the variations of bamboo leaf powder on glutinous rice flour were 0, 1, 3, 5 and 7 % (w/w), respectively. Results showed that the best bioplastic composition was 5% (w/w) bamboo leaf powder addition on glutinous rice flour. As the conclusion, addition of bamboo leaf powder to reinforce bioplastic composite of glutinous rice flour was able to enhance the thickness, hardness and tensile strength significantly. Meanwhile, the value of density, elongation, and water vapor transmission rate showed a slight increase. Keywords: bioplastic- bamboo leaf powder- hydrothermal- glutinous rice flour- psycho-mechanic properties- Share Link | Plain Format | Corresponding Author (Uma Fadzilia Arifin)

32	Material and Applied Chemistry	ABS-49
Facile Modification of Natural Bentonite as a Cationic Dyes Removal Yusuf Mathiinul Hakim1, b), Risfidian Mohadi2, a), Idha Royani3, c), Mardiyanto4, d) 1 Department of Environmental Science, Graduate School Sriwijaya University, Palembang, 30139, Indonesia. 2 Department of Chemistry, Faculty of Mathematics and Natural Sciences, Sriwijaya University, Palembang, 30662, Indonesia. 3 Department of Physics, Faculty of Mathematics and Natural Sciences, Sriwijaya University, Palembang, 30662, Indonesia. 4 Pharmaceutical Department, Faculty of Mathematics and Natural Sciences, Sriwijaya University, Palembang, 30662, Indonesia. a) Corresponding author: risfidian.mohadi[at]unsri.ac.id b) yusufmathiinul191[at]gmail.com c) idharoyani[at]unsri.ac.id d) mardiyanto[at]mipa.unsri.ac.id Abstract The existence of bentonite is massively explored for a broad spectrum of applications. Optimization of bentonite was carried out through various modification methods to increase adsorption capacity. In this study, optimization of bentonite from Pacitan, Indonesia was carried out by pillarization method using Sodium (Na+) and Ammonium (NH4+) ion which affected to increasing the layer size of bentonite structure effect to increased adsorption capacity. The structural changes are indicated by an XRD spectra shift in the peaks range of 20[degree]-28[degree] due to differences in cations. The FTIR spectra confirmed a specific shift in wavelength of 3433 cm-1 due to the size of the cations. The results of the adsorption selectivity showed that bentonite-based adsorbents tended to readily adsorb Malachite Green in a mixed solution of cationic dyes (Rhodamine B and Malachite Green). Evaluation of the adsorption of Bentonite, Bentonite-Na, and Bentonite-NH showed an enhancement in capacity adsorbed of 100 mg.g-1, 116.279 mg.g-1, 526.316 mg.g-1 against Rhodamine B, respectively, and 109.890 mg.g-1, 123.457 mg.g-1, 128.205 mg.g-1 against Malachite Green, respectively. The kinetic studies display adsorption mechanism follows a pseudo-second order model. The thermodynamic parameters show that the reactions occur spontaneously and are endothermic. Keywords: Bentonite Intercalation, Cationic Dyes, Selectivity, Kinetics, Thermodynamics. Share Link | Plain Format | Corresponding Author (Yusuf Mathiinul Hakim)

33	Material and Applied Chemistry	ABS-52
Ethanolic Extract of Guava Seed Leaves (Psidium guajava L.) as Media for Biosynthesis of ZnO Nanoparticles : Characterization and In Vitro Study to Escherichia coli Bacteria Ahmad Fatoni1,a), Ika Oktania2), Yopi Rikmasari1) and Nurlisa Hidayati3) Sekolah Tinggi Ilmu Farmasi Bhakti Pertiwi Abstract The biosynthesis of ZnO nanoparticles 1 and 2 was researched. Biosynthesis of ZnO nanoparticles, their characterization, and, its application as an antibacterial agent of Escherichia coli was the goal of this research. ZnO nanoparticles 1 were biosynthesized by the media of ethanolic extract of guava seed leaves (Psidium guajava L.), zinc ion, and an alkaline solution. ZnO nanoparticles 2 were biosynthesized without an alkaline solution. FTIR spectroscopy and X-ray diffractions are the instruments to analyze functional groups and physical structure of ZnO nanoparticles 1 and 2. The suspension of ZnO nanoparticles 1 and 2 was used as an antibacterial agent with the well agar diffusion method. The Zn-O group at ZnO nanoparticles 1 and 2 has a wavenumber at 470.63 and 675.09-617.22 cm-1 respectively. The crystallite size of ZnO nanoparticles 1 and 2 was estimated at 7.01 and 14.14 nm respectively. At the concentration of 0.5 and 1 % (w/v), ZnO nanoparticles 1 and 2 have the same average diameter inhibition zone to Escherichia coli bacteria. Keywords: ZnO nanoparticles- characterization- antibacterial Share Link | Plain Format | Corresponding Author (Ahmad Fatoni)

34	Material and Applied Chemistry	ABS-54
Synthesis and Modified Hydroxyapatite and It Antibacterial Effect Agaist Oral and Respiratory Bacteries Agung Rimayanto Gintu Universitas Kristen Satya Wacana, Salatiga Abstract Keywords: Bioceramics, Biomaterials, Bones, Hydroxyapatite Share Link | Plain Format | Corresponding Author (Agung Rimayanto Gintu)

35	Material and Applied Chemistry	ABS-61
Mapping the Patent Landscape of Polyurethane-based Anti-corrosion Coatings with Comprehensive Network Analysis Jared Deve P. Delicana, Arnold C. Alguno Mindanao State University-Iligan Institute of Technology Abstract Polyurethane-based anti-corrosion coatings has drawn a lot of attention in industry due to its superior anti-corrosion properties like its exemplary hardness and anti-abrasion. Although this material is very promising, there has been no formal analysis on its technologies stored in patent documents. This study navigates the diverse patent technologies by scrutinizing a dataset of 10,300 patents developed by 30 countries from 2001-2021. Graphs and chart are generated to see trends in categorized patent information. Cognitive networks are generated as well as the entropy and diversity of each of the patenting regions. Heat map locate gaps in technological development as well as highlight prolific patenting countries. China is the top player in terms of the number of published patents. Large chemical manufacturers like BASF coating from Germany and multinational steel corporation like the Nippon Steel Corp from Japan shows large interest on polyurethane-based anti-corrosion coatings. Keywords: polyurethane-based anti-corrosion coatings, patents, network analysis, Share Link | Plain Format | Corresponding Author (Jared Deve Padua Delicana)

36	Material and Applied Chemistry	ABS-62
Ability Test of C-4-Methoxyphenyl-Calix[4]resorcinarene as An Inhibitor of Calcium Carbonate (CaCO3) Crust Growth at Various Concentration Suryadi Budi Utomo, Lathifah Ramadhani, Kisti Makrifatul Hanifah, and Elfi Susanti V.H Department of Chemistry Education, FKIP, Universitas Sebelas Maret Jl. Ir. Sutami No. 36A, Surakarta, Central Java, Indonesia 57126 Abstract The aim of this research were to determine the ability of C-4-methoxyphenyl-calix[4]resorcinarene to inhibit the formation of CaCO3 crust in several concentrations of inhibitor and various time. The research method used is an experimental laboratory method, using a growth solution of 0.1 M and concentrations of C-4-methoxyphenyl-calix[4]resorcinarene of 0, 5, 10, 20 and 40 ppm. The working procedure begins with the preparation of seed crystals which will be used to determine the rate of crystal growth. The results of this research obtained that the C-4-methoxyphenyl-calix[4]resorcinarene compound can inhibit the scale formation rate of CaCO3. The use of C-4-methoxyphenyl-calix[4]resorcinarene as an inhibitor of CaCO3 scale can be effective if it is balanced with temperature control in the heating process. The greater concentration of inhibitor the more effective in inhibiting the growth of CaCO3 scale. The most effective scale reduction occurs at the inhibitor concentration of 20 ppm at contact time of 40 minutes. Calixarene acts as a scale growth inhibitor by absorb metal ions of Ca2+ using several active functional group so that crust cannot be formed Keywords: C-4-methoxyphenyl-calix[4]resorcinarene, CaCO3, scale formation rate, inhibitor Share Link | Plain Format | Corresponding Author (Suryadi Budi Utomo)

37	Material and Applied Chemistry	ABS-63
In Silico Cytotoxicity Prediction of Nanoparticles by Artificial Neural Networks Gabriel Engcong (1, 2, a), Irelie Ebardo (1, 2, b), Phoebe Sombilon (1, c), Mikee Joy Rodriguez (1, d), John Riz Bagnol (3, e), Lilibeth Coronel (4, f), Mary Joy Latayada (5, g), Jay Michael Macalalag (5, h), Farlley Bondaug (1, i), Arnold Alguno (6, j), and Rey Capangpangan (1,4, k) Author Affiliations 1) REY Laboratories, Research Division, Mindanao State University at Naawan, Naawan, 9023, Philippines 2) Department of Science and Technology - Science Education Institute, General Santos Avenue, Bicutan, 1631, Taguig City 3) The University of Southeastern Philippines, F. Inigo St., Barrio Obrero, Davao City, 8000, Philippines 4) College of Marine and Allied Sciences, Mindanao State University at Naawan, Naawan, 9023, Philippines 5) Caraga State University, Ampayon, Butuan City, 8600, Philippines 6) Department of Physics, Mindanao State University-Iligan Institute of Texhnology, Tibanga, 9200, Iligan City Author Emails a) gabriel.engcong[at]msunaawan.edu.ph b) irelie.ebardo[at]msunaawan.edu.ph c) phoebe.sombilon[at]msunaawan.edu.ph d) mikeejoy.rodriguez[at]msunaawan.edu.ph e) jrbagnol[at]usep.edu.ph f) lilibeth.coronel[at]msunaawan.edu.ph g) mrlatayada[at]carsu.edu.ph h) jrmacalalag[at]carsu.edu.ph i) farlley.bondaug[at]msunaawan.edu.ph j) arnold.alguno[at]g.msuiit.edu.ph k) rey.capangpangan[at]msunaawan.edu.ph Abstract Information on the toxicity behavior of nanomaterials (NMs) is of vital importance to ensure that its delivery to biological targets causes no adverse effects. Some engineered NMs present new and unusual hazards. However, there is very little information on how their toxicity can be identified, assessed, and even controlled. NMs toxicity evaluation is normally evaluated through in vitro toxicity or animal testing. However, these modes of toxicity evaluation, aside from being expensive, require long analysis time and are being questioned for ethical considerations. Furthermore, the reliability and reproducibility of animal studies within species are also questionable even if the experiment is being done under rigorous protocol. Hence, our research is driven towards the development of in silico predictive models in assessing the cytotoxicity of the different NMs. Artificial neural networks (ANNs) are a class of machine learning models that have been successfully applied in the field of chemical sciences to develop quantitative structure-activity relationship models for chemical activities of compounds. This paper applied ANN to build predictive models for nanoparticle (NP) cytotoxicity. The models are trained on a heterogeneous dataset on NP cytotoxicity obtained from a comprehensive literature review. Neural network models for binary classification and regression are both considered and are separately investigated. Shallow network architectures with up to 2,048 units per hidden layer were explored for each model. The selected models for the binary classification task showed prediction accuracies in the range of 80% - 93% while the models for the regression task showed mean absolute errors (MAE) in the range of 14% - 23%. Results show that excessively large datasets are not necessary to obtain optimal predictive performance and that the choice of the selected features for the models greatly impact predictive performance on both the classification and regression tasks. Keywords: Nanotoxicity, In silico model, Cytotoxicity prediction, Artificial Neural Network, Classification, Regression Share Link | Plain Format | Corresponding Author (Irelie Pulgo Ebardo)

38	Material and Applied Chemistry	ABS-70
Electrosprayed Chitosan Nanoparticles For Drug Carriers In Cancer Treatment Muchfi Azizah, Fatoni Udaneni, Dewanto Harjunowibowo, Yulianto Agung Rezeki Physics Education, Faculty of Teacher Training and Education, Universitas Sebelas Maret, Ir. Sutami 36 Kentingan Street, Jebres, Surakarta, Indonesia. Abstract Nanoparticles are colloidal particles that range in size from 1-100 nanometers and have unique properties that influence their application and production. The method used in writing this article is a literature review, which aims to discuss the use of chitosan nanoparticles produced by the electrospray technique as a drug carrier in treating cancer cases. The previous studies have stated that nanoparticles are very well used for the treatment of cancer because nanoparticles can distribute medications locally to the tumor site without causing side effects during the drug delivery process. Chitosan nanoparticles can efficiently deliver medications to specific areas by retaining drugs locally for a long time to allow for drug absorption. This is due to the influence on the process of producing nanoparticles. Chitosan nanoparticles can be used as drug carriers in nanoparticle production using the electrospray technique, which can meet various demands for nanoparticle production, including reproducibility, scalability, and effective encapsulation. Furthermore, this technology employs the spray combustion principle, which is in high demand and a current trend due to its ease of use. This article describes several studies that have been carried out regarding the use of electrosprayed chitosan nanoparticles to encapsulate various drugs due to their active surface absorption, binding, or complexation with drugs. Keywords: Nanoparticles, Chitosan, Electrospray, Cancer Treatment Share Link | Plain Format | Corresponding Author (Muchfi Azizah)

39	Material and Applied Chemistry	ABS-74
PREPARATION AND CHARACTERIZATION OF CROSS-LINKED CHITOSAN MEMBRANES ZINC AS AMOXICILLIN PHARMACEUTICAL WASTE ADSORBENT Rizki Nur Isnaini Universitas Sebelas Maret Abstract This study aims to determine (1) Knowing how to synthesize Zinc crosslinked Chitosan membrane (2) To characterize Zinc crosslinked Chitosan membrane with Fourier Transform Infrared (FTIR), X-Ray Diffraction (XRD), and Scanning Electron Microscopy (SEM) ( 3)Knowing the adsorption effectiveness of Zinc crosslinked Chitosan membrane against amoxicillin waste with the effect of contact time (4) Knowing the effectiveness of Zinc crosslinked Chitosan membrane adsorption on amoxicillin waste with the effect of adsorbate concentration and (5) Knowing the maximum adsorption capacity of amoxicillin waste. This study uses experimental methods in the laboratory.The working procedure in this study was to make a Zinc crosslinked Chitosan membrane with variations in the molarity of Chitosan and Zinc and oven it at a temperature of 500C for 14 hours. The membrane that has dried thencharacterized using FTIR, SEM and XRD. Then, meThe membranes were cut 2x2 cm and then contacted with amoxicillin waste using the batch method for a variation of time (15,30,45,60,90,120 minutes). The resulting solution was then filtered and the amoxicillin waste filtrate was obtained. The filtrate obtained lastcharacterized using a UV-Vis Spectrophotometer. The results showed that: (1) Zinc crosslinked Chitosan membrane was successfully synthesized (2)Based on the results of FTIR characterization, there are hydroxyl groups (OH), carbonyl groups (CO), amine groups (-NH2) and interactions between N-Zn and O-Zn on the synthesized membrane. XRD characterization showed that the Zinc crosslinked Chitosan membrane had a semicrystalline structure. Zinc crosslinked chitosan membrane shows uneven and wavy surface morphology of the membrane(3) Chitosan MembraneZinc crosslinked has maximum adsorption effectiveness at contact time of 60 minutes(4) Chitosan MembraneZinc crosslinked has a maximum adsorption effectiveness value at a concentration of 60 mg/L and (5) The maximum adsorption capacity of Zinc crosslinked chi Keywords: Chitosan, Zinc, Membrane, Adsorption, Waste Amoxicillin Share Link | Plain Format | Corresponding Author (RIZKI NUR ISNAINI)

40	Material and Applied Chemistry	ABS-79
The Roles of Amphiphilic Triblock Copolymer P123 in Synthesis of Iron Oxide Particle: Review Maria Ulfa1a) Shabrina1 1,2 Chemical Education Study Program, Faculty of Teacher Training and Education, Sebelas Maret University, Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java Indonesia Abstract In this review, iron atom-supported on certain materials through sol-gel hydrothermal treatment using non-ionic surfactant (Pluronic P123) has been studied. The amphiphilic triblock copolymer P123 as not only a template and but also a precursor of carbon material. The ratio between the Pluronic P123 and iron precursor have significant effect to control the structural and textural properties of resulting material. Triblock copolymer P123 have the positif effect to control the aggregation and oxidation of Fe particles and this scope have been studied as the technical challenges development. The various surface modification and particle stabilization strategies have been developed by controlling the use of Triblock copolymer P123 Keywords: Iron oxide, P123, template, aggregation, surface modification, structure, texture Share Link | Plain Format | Corresponding Author (Shabrina Devinta Poetry)

41	Material and Applied Chemistry	ABS-80
The Change of Structure TiO2 Use P123 As Template: Review Maria Ulfa1a) INDRIYANI PANGESTUTI1 1,2Chemical Education Study Program, Faculty of Teacher Training and Education, Sebelas Maret University, Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java Indonesia Abstract Pluronics P123 have emerged as a potential agent for solubilizing a variety of metal oxide precursor molecules, but how these solubilizates affect the morphology of material still remains poorly understood. In this review, the morphological transition of TiO2 induced by Pluronic P123 micelles has been comprehensively investigated. The change of TiO2 structure by P123 micelles form micellar clusters are governed by the balance of hydrophobic interaction and hydrogen bonding, which consequently leads to the varying micellar morphologies. The review results are further also show that the intensity of Pluronic-TiO2 interaction increases with the hydrophobicity of the P123, indicating that hydrophobic interaction is more important on the TiO2 morphological transition. Finally, the mechanism of morphological transition induced by various P123 concentration, time, temperature and acidity and discussed for for evaluate the structure formation of of TiO2 Keywords: TiO2, P123, the change properties, application, concentration, time, temperature Share Link | Plain Format | Corresponding Author (Indriyani Pangestuti)

42	Material and Applied Chemistry	ABS-81
REVIEW THE SURFACE AREA INVESTITAION ON Fe- TiO2 SYNTHESIS BY P123 TEMPLATING:REVIEW Maria Ulfa 1a), Nina 1 Sebelas Maret University Abstract Fe- TiO2 powders with a high specific surface area were reviewed by P123 solgel syntheses. The influence of the triblock copolymer P123 on specific surface area and photocatalysis as application was reviewed by filtering 1250 paper to 50 specific paper from https://www.sciencedirect.com/search?qs=Fe-Ti%2C%20p123 by keyword Fe, Ti, P123 . the character of Fe-Ti reviewed by analysis the X-ray powder diffraction (XRD), thermogravimetric analysis (TG-DTA), measurements of the specific surface area (sBET), field-emission scanning electron microscopy (FE-SEM) and transmission electron microscopy (TEM). The photocatalytic activity under UV (ultraviolet) irradiation was analysed by method comparison. The review conclude that the application of P123 increased the specific surface area of the samples, inhibited the particle growth during the thermal treatment and stabilized the crystal phase at higher annealing temperatures Keywords: TiO2, P123, surfactan, application, concentration, time, temperature Share Link | Plain Format | Corresponding Author (Nina nina)

43	Material and Applied Chemistry	ABS-82
Structural transformation of titania use CTAC as stabilizer: Review Maria Ulfa1a) Wieke Helma Anjelina1 1,2Chemical Education Study Program, Faculty of Teacher Training and Education, Sebelas Maret University, Jl. Ir. Sutami 36 A, Surakarta 57126, Central Java Indonesia Abstract In this review, the study of the synthesis of titania of different shapes in the presence of cetyltrimethylammonium chloride (CTAC) as the most popular stabilizers for directly tuning the morphology and dimensions have been investigated. These CTAC as stabilizers usually allow the synthesis of titania with a narrow size distribution and mostly single-crystalline structures in high yields. A number of excellent paper on the synthesis of titania are available but while few articles specifically focus on the synthesis of titania using or CTAC as stabilizers due to the CTAC stabilizers have the same structure except for the anions. The general rule for the shape transformation of titania by CTAC as stabilizers can be easily summarizes based the literature on the last ten year from https://www.sciencedirect.com/ as source. Keywords: titania, CTAC, template, stabilizer, aggregation, surface modification, structure, texture Share Link | Plain Format | Corresponding Author (Wieke Helma Anjelina Anjelina)

44	Material and Applied Chemistry	ABS-96
Synthesis of Colloidal Silver Nanoparticles Using Alginate as Reducing and Stabilizing Agent and its Application as Antibacterial Material Endang Susilowati, Lina Mahardiani, Sri Retno Dwi Ariani, and Hidayat Fauzi Universitas Sebelas Maret Abstract Colloidal silver nanoparticles (AgNps) were synthesized using AgNO3 as precursor, NaOH as accelerator reagent and alginate as reducing agent as well as stabilizer. The effect of temperature, accelerator concentration, time and precursor concentration were investigated based on localized surface plasmon resonance (LSPR) phenomenon using UV-Vis spectrophotometer. The size distribution of nanoparticles were observed using Particle Size Analyzer (PSA). The stability of silver-alginate nanocomposites were tested for 8 weeks based on the LSPR phenomenon. Colloidal AgNps were tested for their antibacterial activity against S. Aureus ATCC 25923 and E. Coli ATCC 25922. The result showed that the number of silver nanoparticles formed were influenced by temperature, time, NaOH concentration, and AgNO3 concentration. At a temperature of 50C, the optimum synthesis of silver-alginate nanocomposites at 50 minutes with concentration of 0.013M NaOH. The higher the AgNO3 concentration, the higher the concentration of silver nanoparticles formed. Based on result of PSA characterization showed that the particle size in the range 0.8 - 5.0 nm. Based on the LSPR phenomenon, colloidal AgNps were stable in storage for 8 weeks at room temperature. The increase in concentration of silver nanoparticle within colloidal will increase antibacterial activity against S. Aureus and E. Coli. Silver-alginate nanocomposites have the potential to be used as an antibacterial material for medical applications. Keywords: Colloidal, silver nanoparticles, alginate, antibacterial Share Link | Plain Format | Corresponding Author (Endang Susilowati)

45	Material and Applied Chemistry	ABS-97
The Development of Durian Seed Powder for Laten Fingerprint Identification Sri Adelila Sari, Ade Novita Sari Lubis, and and Dinda Hawari Universitas Negeri Medan Abstract Fingerprinting is a forensic science used in criminal investigations. The method most often used in fingerprints is the dusting method because it is relatively simple and easy. However, some of the chemical substrates used are toxic and potentially harmful to health. To overcome this problem, the development of fingerprints using durian seed powder is easier to obtain and provides a clear print. The results of development using durian seed powder, the size of 100 mesh and 200 mesh on the surface of aluminum foil and glass preparations providing a clear visualization of fingerprint patterns and good color contrast. Meanwhile, the powder sizes of 60 mesh and 80 mesh resulted in poor visualization. The highest percentage of fingerprint patterns formed based on ethnicity was the loop pattern of 21.1% in the Malay ethnic group, 20% for the Batak tribe, and 17.7% for the Batak tribe. The highest percentage of fingerprint patterns formed based on blood group were the loop pattern of blood type O 31.1%, blood group B 12.2%, blood group AB 8.8%, and blood group A 6.6%. The highest percentage of fingerprint patterns that were formed based on gender was the loop pattern 45.5% for women, and 13.3% for men. Keywords: Durian seed, and Latent fingerprint Share Link | Plain Format | Corresponding Author (Sri Sari)

46	Material and Applied Chemistry	ABS-98
Modification and Characterization of Shellac Through Hydrolysis and Polyesterification as Biocomposite Nanik Dwi Nurhayati Faculty of Teaching and Education, Sebelas Maret University, Surakarta Abstract The aim of this study was to improve shellac properties through modification of the hydrolysis and polyesterification processes. The process of hydrolysis by extraction uses NaOH. The process of polyesterification with the addition of phthalic anhydride in the varied concentration of 5%, 10%, 15%, 20% and 25% w/w. The analysis results showed an absorption in the intensity shellac hydrolyzed and shellac polyesterification caused to the hydrolysis process which resulted in the break of natural shellac polyester groups into carboxylic monomers (-COOH) as evidenced by a strongly the absorption of the hydroxyl group at 3425,58 cm-1 indicates the hydroxyl group is not hydrogen bond and the reduced CO absorption at 1300-1000 cm-1 is a characteristic of the ester group. Shellac polyesterification with phthalic anhydride showed absorption at 2931,75 cm-1 the presence of an alkane group (-CH). Absorption at 1450,47 cm-1 presence of methylene group and absorption at 740,67 cm-1 the presence of a benzene ring phthalic anhydride supported by the absorption of the carbonyl group 1249,87cm-1. Analysis the value acid of natural shellac was increased after the hydrolysis process to 6,79 because the ester shellac bonds (C=O) were broken into carboxyl groups (-COOH) and the number of hydroxyl groups (-OH) increased. The polyesterification process caused the acid value is decrease because added shellac with phthalic anhydride to acidic properties and releases H+ so that shellac becomes acidic than addition-crosslinking between the -OH group in shellac so the number of C=O groups increases and the OH group decreases cause in increased acidity. Analysis intrinsic viscosity shellac of 36,77mL/g and hydrolysis shellac 29,44 mL/g. The optimum modification of polyesterification of shellac-phthalic anhydride of 48,36 mL/g indicated a reaction between shellac with phthalic anhydride so that the polymer chain formed the longer occurs in the straight-chain -OH group. Keywords: shellac, modification, physicochemical, polyesterification, solid-state reaction Share Link | Plain Format | Corresponding Author (Dr. Nanik Dwi Nurhayati, S.Si, M.Si Nurhayati)

47	Material and Applied Chemistry	ABS-103
Carrageenan as an alternative Matrix of Drug Release Tablets Budi Hastuti, Saptono Hadi and Khofidatul Husna Department of Chemistry Education, Faculty of Teacher Training and Education, Sebelas Maret University Department of Pharmacy, Faculty of Mathematics and Natural Sciences,Universitas Sebelas Maret, Jl. Ir. Sutami 36A Surakarta, Indonesia Abstract Carrageenan is a natural polymer produced from seaweed. The purpose of this review article is to provide a literature review on carrageenan drug delivery matrices as an alternative to tablet matrix. The tablet matrix commonly used is cellulose ether group such as hydroxy propyl methyl cellulose (HPMC), hydroxy propyl cellulose (HPC) and sodium carboxy methyl cellulose (Na CMC). This synthetic cellulose ether group is widely used because it has good swelling and compressibility properties. Carrageenan as a component of tablet matrix for drug delivery applications is quite potential because carrageenan has a large molecular weight and has high viscosity and ability to form gels. Thus carrageenan needs to be developed further in an effort to develop it as a tablet matrix, which of course requires a good knowledge of the physicochemical characteristics of carrageenan. Keywords: carrageenan, matrix system, gel formation Share Link | Plain Format | Corresponding Author (Budi Hastuti)

48	Organic Chemistry	ABS-14
Heck Cyclization of 6-Bromo-4-O-methylconiferyl Acrylate Ester: A Preliminary Study of Podophyllotoxin Synthesis from Eugenol Budi Arifin (1*), Yana Maolana Syah (1), and Didin Mujahidin (1) 1) Chemistry Study Program, Bandung Institute of Technology Abstract Podophyllotoxin is an aryltetralin lactone lignan with antiviral and anticancer properties. The demand for podophyllotoxin as a starting material for semisynthesis of more active derivatives is increasing. One method for producing podophyllotoxin is through chemical synthesis. Lignan is comprised of two phenylpropanoid units, so it can be synthesized from other phenylpropanoid molecules, one of which is eugenol, a primary constituent of clove essential oil. The potential for eugenol as a starting material for lignan is enormous because Indonesia is the world^s leading clove producer. For podophyllotoxin synthesis from eugenol, we proposed a new method synthesizing a 6-bromoconiferyl ester from eugenol, followed by a Heck-tandem cyclization of the ester. This paper presents the results of a preliminary study of Heck-tandem cyclization of the 6-bromo-4-O-methylconiferyl acrylate ester to a simpler podophyllotoxin analogue. The acrylic ester was synthesized from eugenol with a yield of 42% in three steps: methylation, bromination, and dehydrobromination-nucleophilic substitution. Heck cyclization was performed in DMF solvent with or without the presence of PPh3 ligand, using different amounts and types of catalyst (PdCl2, Pd(OAc)2, Pd(PPh3)4, and PdCl2(PPh3)2) and base (K2CO3, Cs2CO3, DBU, Et3N, and NaOAc),. However, under the various reaction conditions examined, the expected cyclization reaction did not occur. The ester hydrolyzes to generate 6-bromo-4-O-methylconiferyl alcohol, which is subsequently oxidized to form 6-bromo-4-O-methylconiferaldehyde when the reaction is prolonged at a high temperature or with a stronger base. The stiffness of the (E)-double bond in the cinnamyl group appears to hinder the molecular structure from bending into the conformation required for coupling between the acrylate^s terminal double bond and the aryl bromide groups. Keywords: Anticancer- Antiviral- Bromination- Clove- Methylation- Palladium- Phenylpropanoid- Share Link | Plain Format | Corresponding Author (Budi Arifin)

49	Organic Chemistry	ABS-32
Chemical Composition, Antioxidant and Antibacterial Activities of Three Species from Kaempferia Rhizomes Essential Oils and Hedonic Test as Aromatherapy Air Freshener Sri Retno Dwi Ariani,1,a Egies Pristia Monica Sari,1 Ema Tri Puspitasari,1 1 Department of Chemistry Education, Faculty of Teacher Training and Education, Universitas Sebelas Maret, Jl. Insinyur Sutami No.36 A Kentingan, Jebres, Surakarta, Jawa Tengah, Indonesia, 57126 Abstract Abstract. Sand ginger (Kaempferia galanga L.), finger root (Kaempferia pandurata Roxb.), and round-rooted galangal (Kaempferia rotunda L.) are included in the empon-empon genus Kaempferia. The purposes of this study were to isolate, identify the chemical components, to determine the antioxidant (IC50) and antibacterial activities of sand ginger, finger root, and round-rooted galangal rhizomes essential oils and its hedonic test as aromatherapy air freshener. Based on the research, the essential oils content of sand ginger (0.83%), finger root (0.80%), and round-rooted galangal (0.75%) rhizomes were obtained. All chemical components contained in the essential oils of sand ginger (10 compounds), finger root (15 compounds), and round-rooted galangal (6 compounds) rhizomes had been identified. The compound with the highest area in sand ginger, finger root, and round-rooted galangal rhizomes respectively cetane (35.17%), trans-beta-ocimene (14.58%), and benzyl benzoate (67.52%). The results of the antioxidant activity test (IC50) of essential oils of sand ginger, finger root, and round-rooted galangal rhizomes respectively were (36.09 ppm=very strong), (50.12 ppm=very strong), and (51.69 ppm=strong). The essential oils of sand ginger and finger root rhizomes had antibacterial activities of Staphylococcus aureus ATCC 25923, with the diameter of the inhibition zone at 100% concentration respectively were 8.47 mm (medium) and 16.97 mm (strong). Only the essential oil of finger root rhizome had antibacterial activity of Escherichia coli ATCC 25922 with an inhibition zone at 100% concentration of 11.85 mm (strong). Based on the results of the hedonic test as aromatherapy air freshener from 30 panelists, the average value of fragrance, freshness, making comfortable, and elegance impression aspects of the essential oils of sand ginger, finger root, and round-rooted galangal rhizomes respectively were (4.00=like), (3.00=enough), and (1.75=dislike). Keywords: Kaempferia, antioxidant, antibacterial, hedonic test Share Link | Plain Format | Corresponding Author (Sri Retno Dwi Ariani)

50	Organic Chemistry	ABS-51
THE INVESTIGATION EFFECT OF ADDITIONAL VEGETABLE OIL ADDITIVES ON THE PROCESS OF MAKING BABY RASH CREAM Siti Fatimah (a)*, Fauzan Adzami Lumumba (a) (a) Department of Chemical Engineering, Universitas Muhammadiyah Surakarta Abstract Diaper rash or diaper rash is a skin disorder that arises due to irritation and inflammation of the baby^s genital area which usually occurs at the age of less than 3 years and most often occurs at the age of 9-12 months. Rashes occur due to several factors including the role of urine, feces, friction, high skin moisture, chemical irritation, improper use of diapers, and the presence of bacterial and fungal inf\ections. One of the treatment and prevention of this rash can be done by giving a cream for baby diaper rash. This study aims to examine the effect of variations in the composition of virgin coconut oil, almond oil, beeswax, aloe vera, and zinc oxide on the preparation of baby diaper rash cream using lavender essential oil. The tests carried out included organoleptic tests, homogeneity tests, pH tests, dispersibility tests, adhesive tests, and stability tests. The most optimal experimental results are in the 7th sample. In the organoleptic test, a white color with a creamy texture and lavender aroma was produced. For homogeneity test obtained homogeneous. The pH obtained is 7.84. Spreading power ranges from 2 cm - 4.5 cm. The stickiness test was obtained with a value of 72 seconds. The results of the stability test in terms of organoleptic and homogeneity both before and after the cycle test, the cream did not change. Meanwhile, during the cycle process, the results of pH, stickiness, and spreadability of the preparation changed with a pH value of 5, adhesion for 99 seconds, and spreadability ranging from 2.5 cm - 4.5 cm Keywords: Diaper rash, cream, vegetable oil Share Link | Plain Format | Corresponding Author (Siti Fatimah)

51	Organic Chemistry	ABS-53
Derivatives of Pyrazine-2-carboxamide and Their Activity as Tyrosine Kinases Inhibitors Widiastuti Agustina Eko Setyowati, Yana Maolana Syah, Ihsanawati, Anita Alni 1. Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institute of Technology Bandung, Indonesia 2. Study Program of Chemistry Education, Faculty of Teacher Training and Education, Sebelas Maret University, Indonesia Abstract Three pyrazine-2-carboxamide derivatives, i.e. 3-amino-N-butylpyrazine-2-carboxamide (1), 3-amino-N-isobutylpyrazine-2-carboxamide (2), and 3-amino-N-(4-methylbenzyl)pyrazine-2-carboxamide (3) have been successfully synthesized from 3-aminopyrazine-2-carboxylic acid. The molecular structures of these compounds were determined based on 1D NMR (1H and 13C), 2D NMR (HMBC and HSQC) and MS spectroscopic data. The three compounds together with the three pyrazine-2-carboxamide derivatives previously reported, i.e. 3-amino-N-phenylpyrazine-2-carboxylic acid (4), 3-hydroxy-6-nitropyrazine-2-carboxamide (5) and 6-fluoro-3-hydroxypyrazine-2-carboxamide (6) were evaluated as inhibitors against eight tyrosine kinases, including AXL1, EPHA1 TRKA, FAK, ITK, JAK3, PYK2, and SYK. The assay was done by the bioluminescence method using a single-dose profile protocol. The results showed that pyrazine 4 has inhibitory activity against AXL1 and TRKA of 41% and 34%, respectively, while pyrazine 3 has inhibitory activity against AXL1 with the inhibitory activity of 21%. Pyrazine-2-carboxamide derivatives containing aromatic chains in the amide group have higher inhibitory activity so they can be lead compounds as tyrosine kinase inhibitors. Keywords: pyrazine derivatives, inhibitor, tyrosine kinase Share Link | Plain Format | Corresponding Author (Widiastuti Agustina Eko Setyowati)

52	Organic Chemistry	ABS-75
Extraction of Anthocyanins from Dried Java Plum Fruits (Syzygium cumini) as Natural Colorants Muhammad Hizbul Wathon, Endang Susilowati, Sri Retno Dwi Ariani Chemistry Education Study Programme, Faculty of Teacher Training and Education, Sebelas Maret University Abstract Anthocyanins are highly coloured, water-soluble and non-toxic compounds which display bright colors such as red, orange, purple, and blue in flowers, fruits, vegetables, leaves, etc. The possible application of anthocyanins is as natural colorants. Java Plum fruits (Syzygium cumini) are considered as non-conventional and rarely consumed fruits which are high in anthocyanins content. This study was conducted to extract, purify, and characterize anthocyanins from dried Java plum fruits. Anthocyanins in this study were extracted from dried Java Plum fruits using acidified water (0.01% HCl, v/v). The crude extracts were then purified using an SPE column packed with Amberlite-XAD7 with sequential elutions. The refined extracts were then analysed and characterised using various techniques to confirm the anthocyanins profiles present in the extracts. Anthocyanins extracted from Java Plum fruits were identified as delphinidin-3-O-diglucoside, petunidin-3-O-diglucoside, and malvidin-3-O-diglucoside. Keywords: Anthocyanins, Java plum, Syzygium cumini, SPE, colorants Share Link | Plain Format | Corresponding Author (Muhammad Hizbul Wathon)

53	Organic Chemistry	ABS-85
Essential oil of Glycosmis stenocarpa (Drake) leaves grown in Hai Duong province, Vietnam Xuan Duy Le1, Phuong Thao Lai Phuong1, Quoc Toan Tran1,2,a, Thi Ngoc Anh Hoang1, Manh Cuong Nguyen1,2, Ton Nu Thuy An3,4 and Thien Hien Tran3,4,b 1Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), Hanoi City, Vietnam 2Graduate University of Science and Technology, Vietnam Academy of Science and Technology (VAST), Hanoi City, Vietnam 3Faculty of Food and Environmental Engineering, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam 4Institute of Applied Technology and Sustainable Development, Nguyen Tat Thanh University, Ho Chi Minh City 700000, Vietnam a tranquoctoan2010[at]gmail.com- b hientt[at]ntt.edu.vn Abstract In this study, we conducted the extraction of essential oil of Vietnamese Glycosmis stenocarpa leaves using two different methods such as conventional microwave-assisted hydro-distillation (MAHD) and hydro-distillation (HD). The obtained products were analyzed by gas chromatography-mass spectrometry (GC-MS). The essential oil performance achieved similarly in two samples. Additionally, GC-MS results revealed that the total chemical ingredients of HD essential oil were 29 compounds and that of MAHD essential oil was 28 constituents. Additionally, chemical constitutes of the two essential oils were similar, with the major components being citronellal, neryl acetate, citronellyl acetate and geranyl acetate. Keywords: Glycosmis stenocarpa (Drake)- essential oil- GC-MS Share Link | Plain Format | Corresponding Author (Thien Hien Tran)

54	Organic Chemistry	ABS-90
SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF HYDROXY CHALCONE Elfi Susanti VH, Sri Mulyani, Sri Retno Dwi Ariani, Suryadi Budi Utomo, M Hizbul Wathon Pendidikan Kimia, FKIP Universitas Sebelas Maret Abstract This study aimed to synthesize 4-hydroxy-4-hydroxy chalcone from 4-hydroxyacetophenone and 4-hydroxybenzaldehyde by grinding technique and determine the antibacterial activity of 4-hydroxy-4-hydroxy chalcone against Staphylococcus aureus and Eschericia coli. Synthesis of 4-hydroxy-4-hydroxy chalcone using the Claisen-Schmidt method of grinding technique by reacting 4-hydroxyacetophenone and 4-hydroxybenzaldehyde for 30 minutes. The grinding results are extracted with chloroform. The crystals formed were tested for purity by Thin Layer Chromatography (TLC) while further purification was carried out by recrystallization. Characterization the chalcone synthesized using FTIR, H-NMR and C-NMR. The synthesized chalcone was tested for antibacterial activity by disc disc method against Staphylococcus aureus and Eschericia coli. The results showed that 4-hydroxy-4-hydroxy chalcone can be synthesized from 4-hydroxyacetophenone and 4-hydroxybenzaldehyde by grinding technique, in the form of slightly shiny orange white crystals (yield of 66.67%) and a melting point of 85-88C. The chalcone has weak antibacterial activity against Staphylococcus aureus and very weak against Eschericia coli. Keywords: hydroxy chalcone, antibacterial, Claisen-schmidt, grinding Share Link | Plain Format | Corresponding Author (Elfi Susanti VH)

55	Pharmacy, and Public Health	ABS-24
Chemical Composition of Covid-19 Vaccine Authorized in Indonesia: Short Review of Public Health Aspects Tonang Dwi Ardyanto1,2, a) ,Nurhasan Agung Prabowo1, 2, b), Risalina Myrtha1,2, c), and Laily Shofiyah Authors Affiliation 1 Universitas Sebelas Maret Hospital, Ahmad Yani Street No 200, Kartasura, Sukoharjo, Indonesia, 57161 2 Faculty of Medicine, Universitas Sebelas Maret, Ir Sutami Street No 36, Kentingan, Jebres, Surakarta, Indonesia, 57126 3. Public Health Magister Program, Graduate School of Sebelas Maret University Author Emails a) Corresponding author:tonang.ardyanto[at]staff.uns.ac.id b) dr.nurhasan21[at]staff.uns.ac.id c)risalinamustarsid[at]staff.uns.ac.id d)lailyshofiyah[at]staff.uns.ac.id Abstract Abstract. Indonesia has been facing COVID-19 since March 2020, causing significant problems for public health. To address this, the vaccination program began in January 2021. Several obstacles were including public acceptance of the composition of the COVID-19 vaccine. We systematically searched Pubmed for peer-reviewed studies examining analyses of the Chemical Composition of the COVID-19 Vaccine authorized in Indonesia. The research included in this review was a study from 2000 to 2022, the full text of the article can be obtained, and the patient^s age is over 18 years. There are four methods of making the COVID-19 vaccine used to date. First is the whole-virus inactivated method. The principle is to weaken the virus with certain chemicals. The second is the viral vector vaccine method by inserting DNA of the SARS-COV-2 virus S protein into another benign viral gene as its carrier. Third is mRNA vaccine methods, by inserting the S protein mRNA from the SARS-CoV-2 virus. The fourth is the recombinant protein method. In all four ways, adding adjuvants and some other chemicals is required. The expansion aims to maintain the content of the vaccine, strengthen the body^s reaction to the vaccine, and facilitate the administration process. But there are concerns about the risk of unintended effects of the substances used. This perception includes those that hinder the implementation of COVID-19 vaccination in Indonesia. There is a need to disseminate information and education about the composition of the vaccine so that the optimal vaccination program benefits the community. Keywords: Covid-19 Vaccine, Composition, Public Health Share Link | Plain Format | Corresponding Author (Tonang Dwi Ardyanto)

56	Pharmacy, and Public Health	ABS-33
Parasitic Zoonosis with Soil as Transmission Media Khesara Sastrin Prasita Negara1, Yulia Sari1, Lilik Wijayanti2, Sri Haryati1, Azzahra Harmalia Anjani3, Alifia Nur Faizah3, Arya Pandu Jatmiko3, Azzahra FA Nisa3 1Department of Parasitology, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia 2Department of Clinical Pathology, Study Program of Medicine, Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia 3Student of Undergraduate Medical Education Program, Faculty of Medicine, Universitas Sebelas Maret Abstract Parasites are one of the causes of the emergence of infections that affect millions of humans in the world ranging from harmless to fatal. Zoonoses are diseases that can naturally be transmitted from animals to humans and vice versa. Zoonoses also apply to a disease-causing organism that lives in an environment such as soil as source of infection. Zoonotic parasitic diseases pose a significant but often overlooked threat to public health, especially in developing countries. Along with the changing times related to increasing migration, international trade, and global warming, it is not surprising that there are significant changes regarding human and animal interactions. This study is to understand the parasitic zoonosis with soil as transmission media. We used literature study using PubMed and Google Scholar. There are primarily Soil Transmitted Helminths (STH) infections in the tropical and subtropical regions of sub-Saharan Africa, the Americas, and Asia, where warm moist environments facilitate worm egg and larvae survival, poor hygiene and sanitation prevail, and limited access to safe water sources. In many areas of Indonesia, the environment and socioeconomic conditions are ideal for STH infections. This needs attention for better health education related to hygiene and sanitation for preventing the parasitic zoonotic incidence both locally in Indonesia and globally worldwide. Keywords: parasitic, zoonosis, soil, transmission media Share Link | Plain Format | Corresponding Author (Khesara Sastrin Prasita Negara)

57	Pharmacy, and Public Health	ABS-34
The Effect of Curcumin on Blood Glucose Patients With Type 2 Diabetes Mellitus: A Systematic Review Nurhasan Agung Prabowo, Yulia Sari, Desy Puspa Putri, and Hartono 1. Universitas Sebelas Maret Hospital, Ahmad Yani Street No 200, Kartasura, Sukoharjo, Indonesia, 57161 2. Faculty of Medicine, Universitas Sebelas Maret, Ir Sutami Street No 36, Kentingan, Jebres, Surakarta, Indonesia, 57126 3. Doctoral Degree of Medical Science Program, Faculty of Medicine, Universitas Sebelas Maret, Ir Sutami Street No 6, Kentingan, Jebres, Surakarta, 57126 Abstract Diabetes Mellitus (DM) type 2 is a chronic disease characterized by elevated blood sugar levels. Curcumin, the active form of Curcuma longa, has blood glucose-lowering activity. This systematic review aimed to identify whether curcumin can reduce blood sugar levels in patients with type 2 diabetes. We systematically searched Pubmed for peer-reviewed studies examining the effects of curcumin on reducing blood glucose in type 2 DM patients. The research included in this review was a study from 2000 to 2022, randomized control trial using intervention curcumin, an outcome variable using blood sugar, the full text of the article can be obtained, and the DM patient^s age is over 18 years. Three reviewers independently extracted data on relevant clinical outcomes, trial characteristics, and patient characteristics and used the Cochrane Risk of Bias Assessment Tool. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation. Three journals meet the requirements. Curcumin has a mechanism of stimulating incretin and inhibiting digestive enzymes so that it can reduce blood sugar levels in type 2 DM patients. Keywords: Curcumin, Blood Glucose, Diabetes Mellitus Share Link | Plain Format | Corresponding Author (Nurhasan Agung Prabowo)

58	Pharmacy, and Public Health	ABS-35
The Effect of Mesenchymal Stem Cell in in The Disease Activity of Rheumatoid Arthritis: A Systematic Review Nurhasan Agung Prabowo, Arief Nurudhin, Desy Puspa Putri, and Yulyani Werdiningsih 1. Universitas Sebelas Maret Hospital, Ahmad Yani Street No 200, Kartasura, Sukoharjo, Indonesia, 57161 2. Faculty of Medicine, Universitas Sebelas Maret, Ir Sutami Street No 36, Kentingan, Jebres, Surakarta, Indonesia, 57126 3. Doctoral Degree of Medical Science Program, Faculty of Medicine, Universitas Sebelas Maret, Ir Sutami Street No 6, Kentingan, Jebres, Surakarta, 57126 Abstract Abstract. Rheumatoid arthritis is a systemic autoimmune disease that causes damage to the joints and can attack other body organs. Stem cells have a role in carrying out regenerative processes in repairing tissues and organs through differentiation of mesenchymal tissue and also act as immunomodulators. The injected mesenchymal stem cells can migrate to the damaged tissue and facilitate the healing of the damaged cells.Therefore, this paper aims to review mesenchymal stem cells in rheumatoid arthritis. We systematically searched Pubmed, Cochrane, and Scopus for peer-reviewed studies examining the effects of mesenchymal stem cells in rheumatoid arthritis. The research included in this review was a study from 2000 to 2022, a randomized control trial using intervention mesenchymal stem cells, the full text of the article can be obtained, and the patient^s age is over 18 years. Three reviewers independently extracted data on relevant clinical outcomes, trial characteristics, and patient characteristics and used the Cochrane Risk of Bias Assessment Tool. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation. A mesenchymal stem cell has a mechanism of anti-inflammation, regenerative, and immunomodulating in rheumatoid arthritis patients. Keywords: Messenchymal stem cell, Rheumatoid Arthritis Share Link | Plain Format | Corresponding Author (Nurhasan Agung Prabowo)

59	Pharmacy, and Public Health	ABS-44
PRELIMINARY STUDY FOR PREPARATION AND CHARACTERIZATION OF RADIOIMMUNOCONJUGATE LU-177-DOTA-RITUXIMAB Veronika Yulianti Susilo1, a) Martalena Ramli1,b) Sri Setiyowati1,c) Abidin1,d) Rien Ritawidya1,e) Titis Sekar Humani1,f) Research Center for Radioisotope, Radiopharmaceutical and Biodosimetry, National Research and Innovation Agency Abstract Requirements of radioimmunotherapy is radionuclides binding to monoclonal antibodies (mAb) were stable and specific recognize tumor associated antigens. Most of the B cell lymphoma express CD20 antigen on the surface of tumor cells, that the target protein CD20 mAb suitable for therapeutic radioactive labeled. In this study, the immunoconjugate of Rituximab and macrocyclic chelator, pSCNBzDOTA, was prepared and radiolabelled using Lutetium177, and then characterized for radiochemical purity of the complex. Rituximab desalted with 0.1 M phosphate buffer pH 8.5 and conjugated with pSCNBz-DOTA in the ratio 1: 20. Result of conjugation was analyzed by high performance liquid chromatography and concentration of protein was measured by protein reader, then dispensing each 2 mg/mL and was dried with a freeze drier. The immunoconjugate was labeled using Lutetium177, the labeling was be carried out with mole ratio variation of DOTA rituximab against Lutetium177 and reaction time. Radiochemical purity of labeling results was characterized using chromatography method with ITLCSG as stationary phase and a mobile phase of 0.9% saline solution. Radiochemical purity of the radioimmunoconjugate complex before purification is 54% in mole ratio of 1:1 and a reaction time of 30 minutes. Radioimmunoconjugate was purified by sephadex G25 column with a yield of purification is 40.03% and radiochemical purity of each fraction on average by 99.98%. Keywords: CD20, rituximab, Lutetium-177, radioimmunotherapy, mAb Share Link | Plain Format | Corresponding Author (Veronika Yulianti Susilo)

60	Pharmacy, and Public Health	ABS-45
Anti-Dandruff Shampoo Formulation from Rambutan Leaf Extract (Nephelium lappaceum L.) as Antifungal Malassezia furfur Hasna Azzahra, Fianicha Shalihah, Siti Aeniah, Inka Pungky Rahmawati, Paula Tyasmita Andar Ningrum, Salma Fauzia Wardani, Intan Muslimah Universitas Sebelas Maret Abstract Shampoo is a product that is used to maintain hair. The most common hair problem is dandruff. Microorganism that cause of dandruff is Malassezia furfur. This fungus can grow quickly if the head has excess oil glands. Rambutan leaf extract contains secondary metabolites that can inhibit fungal growth. Alkaloids can inhibit the growth of fungi because fungi can grow well at pH of 3,8 - 5,6. Flavonoids and tannins can cause damage to cell membrane proteins, causing changes in membrane permeability and fungal cell membrane lysis. Saponins can break down fungal cells. The method used in making the formulation of this rambutan leaf extract shampoo is making rambutan leaf extract, making shampoo, growing test mushrooms on PDA media, making test mushroom suspensions, research and data collection. The data were obtained by measuring the diameter of the inhibition zone of the Malassezia furfur fungus which had been smeared with shampoo from rambutan leaf extract on disc paper. Data from the One Way Anova test on signification 0.000<0.005, so the average test sample has a significant effect. Therefore, the rambutan leaf extract shampoo (10%, 15%, and 30% concentration) can inhibit the growth of the Malassezia furfur fungus in a strong category. Keywords: Malassezia furfur, rambutan leaves, anti-dandruff, shampoo, anti-fungal. Share Link | Plain Format | Corresponding Author (Hasna Azzahra)

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