SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF HYDROXY CHALCONE
Elfi Susanti VH, Sri Mulyani, Sri Retno Dwi Ariani, Suryadi Budi Utomo, M Hizbul Wathon

Pendidikan Kimia, FKIP
Universitas Sebelas Maret

Abstract

This study aimed to synthesize 4-hydroxy-4-hydroxy chalcone from 4-hydroxyacetophenone and 4-hydroxybenzaldehyde by grinding technique and determine the antibacterial activity of 4-hydroxy-4-hydroxy chalcone against Staphylococcus aureus and Eschericia coli. Synthesis of 4-hydroxy-4-hydroxy chalcone using the Claisen-Schmidt method of grinding technique by reacting 4-hydroxyacetophenone and 4-hydroxybenzaldehyde for 30 minutes. The grinding results are extracted with chloroform. The crystals formed were tested for purity by Thin Layer Chromatography (TLC) while further purification was carried out by recrystallization. Characterization the chalcone synthesized using FTIR, H-NMR and C-NMR. The synthesized chalcone was tested for antibacterial activity by disc disc method against Staphylococcus aureus and Eschericia coli. The results showed that 4-hydroxy-4-hydroxy chalcone can be synthesized from 4-hydroxyacetophenone and 4-hydroxybenzaldehyde by grinding technique, in the form of slightly shiny orange white crystals (yield of 66.67%) and a melting point of 85-88C. The chalcone has weak antibacterial activity against Staphylococcus aureus and very weak against Eschericia coli.

Keywords: hydroxy chalcone, antibacterial, Claisen-schmidt, grinding

Topic: Organic Chemistry