Anti-Dandruff Shampoo Formulation from Rambutan Leaf Extract (Nephelium lappaceum L.) as Antifungal Malassezia furfur
Hasna Azzahra, Fianicha Shalihah, Siti Aeniah, Inka Pungky Rahmawati, Paula Tyasmita Andar Ningrum, Salma Fauzia Wardani, Intan Muslimah

Universitas Sebelas Maret

Abstract

Shampoo is a product that is used to maintain hair. The most common hair problem is dandruff. Microorganism that cause of dandruff is Malassezia furfur. This fungus can grow quickly if the head has excess oil glands. Rambutan leaf extract contains secondary metabolites that can inhibit fungal growth. Alkaloids can inhibit the growth of fungi because fungi can grow well at pH of 3,8 - 5,6. Flavonoids and tannins can cause damage to cell membrane proteins, causing changes in membrane permeability and fungal cell membrane lysis. Saponins can break down fungal cells. The method used in making the formulation of this rambutan leaf extract shampoo is making rambutan leaf extract, making shampoo, growing test mushrooms on PDA media, making test mushroom suspensions, research and data collection. The data were obtained by measuring the diameter of the inhibition zone of the Malassezia furfur fungus which had been smeared with shampoo from rambutan leaf extract on disc paper. Data from the One Way Anova test on signification 0.000<0.005, so the average test sample has a significant effect. Therefore, the rambutan leaf extract shampoo (10%, 15%, and 30% concentration) can inhibit the growth of the Malassezia furfur fungus in a strong category.

Keywords: Malassezia furfur, rambutan leaves, anti-dandruff, shampoo, anti-fungal.

Topic: Pharmacy, and Public Health