The Effect of Mesenchymal Stem Cell in in The Disease Activity of Rheumatoid Arthritis: A Systematic Review
Nurhasan Agung Prabowo, Arief Nurudhin, Desy Puspa Putri, and Yulyani Werdiningsih

1. Universitas Sebelas Maret Hospital, Ahmad Yani Street No 200, Kartasura, Sukoharjo, Indonesia, 57161
2. Faculty of Medicine, Universitas Sebelas Maret, Ir Sutami Street No 36, Kentingan, Jebres, Surakarta, Indonesia, 57126
3. Doctoral Degree of Medical Science Program, Faculty of Medicine, Universitas Sebelas Maret, Ir Sutami Street No 6, Kentingan, Jebres, Surakarta, 57126

Abstract

Abstract. Rheumatoid arthritis is a systemic autoimmune disease that causes damage to the joints and can attack other body organs. Stem cells have a role in carrying out regenerative processes in repairing tissues and organs through differentiation of mesenchymal tissue and also act as immunomodulators. The injected mesenchymal stem cells can migrate to the damaged tissue and facilitate the healing of the damaged cells.Therefore, this paper aims to review mesenchymal stem cells in rheumatoid arthritis. We systematically searched Pubmed, Cochrane, and Scopus for peer-reviewed studies examining the effects of mesenchymal stem cells in rheumatoid arthritis. The research included in this review was a study from 2000 to 2022, a randomized control trial using intervention mesenchymal stem cells, the full text of the article can be obtained, and the patient^s age is over 18 years. Three reviewers independently extracted data on relevant clinical outcomes, trial characteristics, and patient characteristics and used the Cochrane Risk of Bias Assessment Tool. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation. A mesenchymal stem cell has a mechanism of anti-inflammation, regenerative, and immunomodulating in rheumatoid arthritis patients.

Keywords: Messenchymal stem cell, Rheumatoid Arthritis

Topic: Pharmacy, and Public Health