Electrosprayed Chitosan Nanoparticles For Drug Carriers In Cancer Treatment Muchfi Azizah, Fatoni Udaneni, Dewanto Harjunowibowo, Yulianto Agung Rezeki
Physics Education, Faculty of Teacher Training and Education, Universitas Sebelas Maret, Ir. Sutami 36 Kentingan Street, Jebres, Surakarta, Indonesia.
Abstract
Nanoparticles are colloidal particles that range in size from 1-100 nanometers and have unique properties that influence their application and production. The method used in writing this article is a literature review, which aims to discuss the use of chitosan nanoparticles produced by the electrospray technique as a drug carrier in treating cancer cases. The previous studies have stated that nanoparticles are very well used for the treatment of cancer because nanoparticles can distribute medications locally to the tumor site without causing side effects during the drug delivery process. Chitosan nanoparticles can efficiently deliver medications to specific areas by retaining drugs locally for a long time to allow for drug absorption. This is due to the influence on the process of producing nanoparticles. Chitosan nanoparticles can be used as drug carriers in nanoparticle production using the electrospray technique, which can meet various demands for nanoparticle production, including reproducibility, scalability, and effective encapsulation. Furthermore, this technology employs the spray combustion principle, which is in high demand and a current trend due to its ease of use. This article describes several studies that have been carried out regarding the use of electrosprayed chitosan nanoparticles to encapsulate various drugs due to their active surface absorption, binding, or complexation with drugs.
Keywords: Nanoparticles, Chitosan, Electrospray, Cancer Treatment
