The Effect of Curcumin on Blood Glucose Patients With Type 2 Diabetes Mellitus: A Systematic Review
Nurhasan Agung Prabowo, Yulia Sari, Desy Puspa Putri, and Hartono

1. Universitas Sebelas Maret Hospital, Ahmad Yani Street No 200, Kartasura, Sukoharjo, Indonesia, 57161
2. Faculty of Medicine, Universitas Sebelas Maret, Ir Sutami Street No 36, Kentingan, Jebres, Surakarta, Indonesia, 57126
3. Doctoral Degree of Medical Science Program, Faculty of Medicine, Universitas Sebelas Maret, Ir Sutami Street No 6, Kentingan, Jebres, Surakarta, 57126

Abstract

Diabetes Mellitus (DM) type 2 is a chronic disease characterized by elevated blood sugar levels. Curcumin, the active form of Curcuma longa, has blood glucose-lowering activity. This systematic review aimed to identify whether curcumin can reduce blood sugar levels in patients with type 2 diabetes. We systematically searched Pubmed for peer-reviewed studies examining the effects of curcumin on reducing blood glucose in type 2 DM patients. The research included in this review was a study from 2000 to 2022, randomized control trial using intervention curcumin, an outcome variable using blood sugar, the full text of the article can be obtained, and the DM patient^s age is over 18 years. Three reviewers independently extracted data on relevant clinical outcomes, trial characteristics, and patient characteristics and used the Cochrane Risk of Bias Assessment Tool. The certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation. Three journals meet the requirements. Curcumin has a mechanism of stimulating incretin and inhibiting digestive enzymes so that it can reduce blood sugar levels in type 2 DM patients.

Keywords: Curcumin, Blood Glucose, Diabetes Mellitus

Topic: Pharmacy, and Public Health