Chemical Composition of Covid-19 Vaccine Authorized in Indonesia: Short Review of Public Health Aspects Tonang Dwi Ardyanto1,2, a) ,Nurhasan Agung Prabowo1, 2, b), Risalina Myrtha1,2, c), and Laily Shofiyah
Authors Affiliation
1 Universitas Sebelas Maret Hospital, Ahmad Yani Street No 200, Kartasura, Sukoharjo, Indonesia, 57161
2 Faculty of Medicine, Universitas Sebelas Maret, Ir Sutami Street No 36, Kentingan, Jebres, Surakarta, Indonesia, 57126
3. Public Health Magister Program, Graduate School of Sebelas Maret University
Author Emails
a) Corresponding author:tonang.ardyanto[at]staff.uns.ac.id
b) dr.nurhasan21[at]staff.uns.ac.id
c)risalinamustarsid[at]staff.uns.ac.id
d)lailyshofiyah[at]staff.uns.ac.id
Abstract
Abstract. Indonesia has been facing COVID-19 since March 2020, causing significant problems for public health. To address this, the vaccination program began in January 2021. Several obstacles were including public acceptance of the composition of the COVID-19 vaccine. We systematically searched Pubmed for peer-reviewed studies examining analyses of the Chemical Composition of the COVID-19 Vaccine authorized in Indonesia. The research included in this review was a study from 2000 to 2022, the full text of the article can be obtained, and the patient^s age is over 18 years. There are four methods of making the COVID-19 vaccine used to date. First is the whole-virus inactivated method. The principle is to weaken the virus with certain chemicals. The second is the viral vector vaccine method by inserting DNA of the SARS-COV-2 virus S protein into another benign viral gene as its carrier. Third is mRNA vaccine methods, by inserting the S protein mRNA from the SARS-CoV-2 virus. The fourth is the recombinant protein method. In all four ways, adding adjuvants and some other chemicals is required. The expansion aims to maintain the content of the vaccine, strengthen the body^s reaction to the vaccine, and facilitate the administration process. But there are concerns about the risk of unintended effects of the substances used. This perception includes those that hinder the implementation of COVID-19 vaccination in Indonesia. There is a need to disseminate information and education about the composition of the vaccine so that the optimal vaccination program benefits the community.
Keywords: Covid-19 Vaccine, Composition, Public Health
