Study the accuracy of OpenDose3D Software Image Registration to Absorbed Dose Calculation of [177Lu]Lu-DOTATATE Patients Aulia Firma (a), Assyifa Rahman Hakim (a), Deni Hardiansyah (a*)
a) Medical Physics and Biophysics, Physics Department, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, Indonesia
*denihardiansyah[at]ui.ac.id
Abstract
This study aims to evaluate the accuracy of image registration on absorbed dose calculations using OpenDose3D software. Patient imaging data were obtained from the Deep Blue Data repository at the University of Michigan Library. The dataset comprises imaging data from patients treated with 177Lu-DOTATATE, including three sequential quantitative SPECT acquisitions at 4-, 24-, 108- and 120- hours post-injection (p.i.), along with a corresponding CT scan acquired at 4 hours p.i. To simulate potential registration mismatches, linear transformations-consisting of rotational and translational adjustments-were systematically applied to the SPECT images. Relative deviation (RD) in absorbed dose (D) was then calculated by comparing transformed images to the original unaltered reference images. The RDs were found to be consistently close to zero in cases where the transformed images were registered to the reference volume. This indicates that the image registration functionality within OpenDose3D-particularly under appropriate acquisition conditions-performs with a high degree of reliability and precision. Therefore, it can be concluded that OpenDose3D is a robust and effective tool for image registration in the context of internal dosimetry following radionuclide therapy.
REFERENCE
[1] Dewaraja, YK., Van, BJ. (2021) Lu-177 DOTATATE Anonymized Patient Datasets: Multi-Time Point Lu-177 SPECT/CT Scans [Data set]. University of Michigan - Deep Blue. https://doi.org/10.7302/0n8e-rz46.
