Increasing the Number of Fibroblasts administering Betel Leaf Extract Gel (Piper Betle L.) to Traumatic Ulcers in Wistar Ratsy to Submit This Sample Abstract Raziv Ganesha, I Gusti Ngurah Putra Dermawan, Intan Kemala Dewi
Faculty of Dentistry University of Mahasaraswati Denpasar
Abstract
Backgrounds: The oral cavity is a place that is very susceptible to irritation or trauma. Trauma is one of the causes of ulceration in the oral cavity and these are known as Ulcer Traumatic. Treatment ulcer traumatic with eliminating the causative factors and anti-inflammatory drugs. The anti-inflammatory drugs that are often given are usually corticosteroids, corticosteroids have the many side effect that^s why we^re doing a lot of research using herbal ingredients. One of the herbal ingredients that is easy to obtain is betel leaf. Fibroblasts have an important role in tissue repair process and role in producing large of collagen. Objectives: the purpose the research is to see an increase the number of fibroblasts in the healing process of traumatic ulcers with the administration of gel leaf extract. Methods: The research used true experiments in vivo where data was taken by observing the number of fibroblasts in tissue excision biopsy preparations on the 3rd, 5th and 7th days after ulcer creation with hematoxylin and eosin staining. The samples used were divided into treatment groups by 45% betel leaf extract gel and control groups by CMC. Results: Results of showed results in P3=34,8 P5= 35,6 dan P7=44 and K3=12,4 K5=21 K7=26,4. Data obtained was then analyzed using Tukey^s Post Hoc test which showed significant differences between groups. Conclusions: The research showed the administration of gel leaf extract 45% can increase the number of fibroblasts compared to CMC to traumatic ulcer in wistar rats
