Resveratrol Effectiveness as Non-Surgical Periodontal Therapy for Periodontitis: A Review Fergy Christin Maitimu1,*, Trijani Suwandi1
1Department of Periodontics, Faculty of Dentistry, Universitas Trisakti, Jakarta, Indonesia
Abstract
ABSTRACT
Background : Resveratrol is a phytoalexin that is naturally produced by different plants. It is commonly found in high quantities in the skin of red grapes and peanuts. Periodontitis is an oral condition that involves inflammation and infection in the tissues surrounding the teeth. This can result in the loss of the alveolar bone and could lead to tooth loss. Research has shown that resveratrol has the ability to reduce the inflammatory response by suppressing the production of inflammatory substances, inhibiting pathogens, promoting tissue regeneration, and bone remodelling. Objective : To obtain some scientific data related to the effectiveness of resveratrol as Non-Surgical Periodontal Therapy for periodontitis. Methods : Using PRISMA (The Preferred Reporting Items for Systematical Reviews and Meta-Analysis) to acquire data about the effectiveness of resveratrol as Non-Surgical Periodontal Therapy for periodontitis. Two databases (Pubmed and Google Scholar) were used from 2014 until May 2024. Result : All the studies matching the search criteria were located. All the studies (Randomized-Clinical Trial and Non-Randomized Clinical Trial) that has been filtered were analysed to find the effectiveness of resveratrol as Non-Surgical Periodontal Therapy for Periodontitis. Conclusion : Resveratrol shows great potential as an additional treatment for periodontitis, particularly when used alongside scaling and root planing as Non-Surgical Periodontal Therapy.
