ACUTE TOXICITY AND ALLERGY TEST OF MORINGA LEAVES (Moringa oleifera) EXTRACT ON MICE (Mus musculus) Mochammad Taha Ma^ruf, Putu Sulistiawati Dewi, Kadek Meidy Xanaya Putri
Universitas Mahasaraswati Denpasar
Abstract
In dentistry, there is growing interest in using moringa extract to accelerate wound healing after tooth extraction. Research on this material has been conducted, so it is necessary to know the safety level of its use, namely the level of toxicity and allergy. This study aimed to assess the acute toxicity and allergic reactions of moringa leaf extract in experimental animals. The acute toxicity test involved administering the extract to mice orally and observing the number of deaths over 24 hours to 14 days. Twenty-five mice were divided into 5 groups receiving different doses of moringa leaf extract, along with a control group. The mice^s body weight was measured to assess acute toxicity, and allergy reactions were observed on the skin. The results indicated that moringa leaf extract is potentially toxic at doses above 2400 mg/kg and falls into the moderate toxicity category. However, there were no signs of skin irritation or allergic reactions in any of the test animals. Therefore, caution is advised when determining the dose of moringa leaf extract due to its potential toxicity.
