Water Extract of Kersen Leaves (Muntingia calabura L.) Reduce Liver Tissue Injury in Mice (Mus musculus) Induced by Alloxan Nur Artri I1a, Putri Felita A I1, Assakina, N. D1, Syarah S W K1,Tejasari M2
Undergraduate Program, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia
Department of Histology Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia
Abstract
Liver injury is a serious medical condition caused by various factors such as oxygen deprivation, exposure to chemical agents, and infections. Drug-induced liver injury (DILI) can manifest as hepatocellular, mitochondrial damage, leading to elevated levels of ALT, AST, and ALP enzymes in the serum, as well as other biochemical disturbances. Objective: This study aims to investigate the protective effects of water-extracted kersen leaves (Mutingia calabura L.) on liver histopathology in mice (Mus musculus) induced with alloxan, a compound known to cause liver injury and hyperglycemia. Methods: The experimental study was conducted using male mice due to their stable hormonal status. Mice were administered alloxan to induce liver injury, followed by treatment with water-extracted kersen leaves. Liver samples were collected and analyzed histopathologically to observe changes in liver tissue, enzyme levels (SGPT and SGOT), and the presence of oxidative stress markers. Results: The study found that treatment with kersen leaf extract significantly reduced liver damage in alloxan-induced mice. Histopathological analysis showed decreased signs of liver cell degeneration, reduced inflammation, and lower levels of oxidative stress markers compared to the control group. Additionally, the kersen leaf extract was effective in lowering blood glucose levels, suggesting its potential as an anti-hyperglycemic agent. Conclusion: Kersen leaf extract demonstrates significant protective effects against alloxan-induced liver injury in mice. These findings support the use of kersen leaves as a potential alternative medicine for liver protection and management of hyperglycemia, aligning with SDGs 3 and 9 by promoting good health, well-being, and innovation in medicinal plant research.
