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The Relationship Between Lipid Profile and Cognitive Function in Ischemic Stroke Patients
Fajar Handika(a), Zahra Khairunnisa Karimah(a), Poca Anida(a), Clarissa Ratna Shamira Hakriadi(a), Mochammad Faisal Afif Mochyadin(b), Alya Tursina(b)

a) Undergraduate Program, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia
b) Department of Neurology, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia


Abstract

Stroke is the second leading cause of death globally, with ischemic stroke accounting for over 62% of cases and cognitive impairment as a frequent complication. Modifiable risk factors like diabetes, hypertension, and LDL cholesterol levels are linked to cognitive decline, with dyslipidemia recognized as a significant risk factor. High serum cholesterol, LDL, and non-HDL cholesterol levels contribute to cognitive impairment due to their atherogenic effects, and studies indicate a correlation between elevated triglyceride and LDL levels and reduced memory abilities. This study aims to analyze and test the hypothesis that there is an association between lipid profiles in this case in ischemic stroke patients with dyslipidemia and hyperlipidemia with cognitive function in ischemic stroke patients. This cross-sectional study involved 55 ischemic stroke patients. Cognitive function was assessed using the MoCA-INA instrument, while lipid profile data were obtained from medical records. Results showed that 70.9% of patients had dyslipidemia, and 29.1% had hyperlipidemia. Among these, 65% of patients with dyslipidemia experienced cognitive impairment, compared to 20% of those with hyperlipidemia. Statistical analysis using the Chi-Square test revealed a significant relationship between lipid profiles and cognitive function in ischemic stroke patients (p=0.024). Discussion highlights that dyslipidemia affects cognitive function through mechanisms such as atherosclerosis and impaired cerebral blood flow. Abnormal lipid profiles, especially elevated LDL and triglycerides, contribute to cognitive decline by exacerbating vascular dysfunction and increasing blood-brain barrier permeability. These findings underscore the importance of lipid profile management, including lifestyle modifications, pharmacological therapy, and dietary interventions, to prevent further cognitive decline in ischemic stroke patients.

Keywords: Lipid profile, dyslipidemia, hyperlipidemia, cognitive function, ischemic stroke, MoCA-INA

Topic: Degenerative Disease

Plain Format | Corresponding Author (Fajar Handika)

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