Comparing Antibacterial Effectiveness of the Emulgel Formulated with Arabica Coffee Java Preanger and Doxycycline Against Cutibacterium Acnes Mia Yasmina Andarini, Mieke Hemiawati Satari, Rd. Anita Indriyanti, Pramudya Adithya, Tiara Natasya
Universitas Islam Bandung
Abstract
Abstract. Cutibacterium acnes (C. acnes) was considered to be the most important causative agent of acne vulgaris (AV) pathogenesis. Oral antibiotics are commonly used as the first line therapy for moderate-severe AV. However, the improper use of antibiotics can contribute to the increased of resistance. With reports of increased resistance to C. acnes bacteria, the management of AV has encountered many problems. The emulgel of Java Preanger Arabica coffee contains a chlorogenic acid molecule with antibacterial properties against C. acnes. The purpose of this study was to determine the antibacterial effect of the emulgel of Java Preanger Arabica coffee and Doxycycline on C. acnes. This study used an in vitro experimental design using C. acnes bacterial isolates. There were four research groups, each consisting of two concentrations of Java Preanger Arabica coffee: 75% and 100%, along with positive control group treated with Doxycycline. These groups were incubated for 24 hours at 37oC, and the inhibition zone diameter was measured in millimeters. The median results indicated that the inhibition zone at a concentration of 100% was 21.72 mm, while at the concentration of 75%, it measured 22.2 mm. In the case of Doxycycline, the median inhibition zone was formed 29.08 mm. The effectiveness of emulgel containing Java Preanger Arabica and Doxycycline at concentrations of 100% and 75% yielded a p value-of 0.001, indicating a significant difference between variables. In conclusion, there is a significant difference in antibacterial effectiveness when comparing emulgel of Java Preanger Arabica coffee and Doxycycline against C. acne.
Keywords: Antibacterial, Arabica coffee, C. acnes, Doxycycline
