The Association Between TILs and Cancer Grading in Breast Cancer Patients at Cibabat Hospital in 2022-2023 Meike Rachmawati,1 Ismet Muchtar Nur,1 Muhammad Syah Misuari Sabirin,1 Rian Robian,2 Adhi Nugraha,2 Rina Melati,3 Aryanti,3 Aninditya Putri Anugrah,4 Nazmy Noor Laila,4 Reyiena Kusumaryani Rahmat,4 Afni Nur Hasanah,4 Nuzirwan Acang,5,6 Wida Purbaningsih,7
1 Department of Anatomy Pathology, Faculty of Medicine, Universitas Islam Bandung
2 Surgical Oncology Installation, Cibabat
Regional General Hospital, Cimahi, Indonesia
3 Laboratory of Anatomy Pathology, Al Islam Hospital, Bandung, Indonesia
4 Biopath Laboratory, Bandung, Indonesia
5 Department of Internal Medicine, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia,
6 Internal Medicine Installation, Cibabat Regional General Hospital, Cimahi, Indonesia
7 Department of Histology,
Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia
Abstract
Breast cancer is the most prevalent malignancy in women globally (154 out of 185 countries) and the world^s fifth-most frequent cause of cancer death. Breast cancer grading and TILs are prognostic factors that can be explained by histology. The purpose of this study is to examine the association between TILs and breast cancer grade in breast cancer patients at Cibabat Hospital. The method used in this research is descriptive-analytic with a cross-sectional design using hematoxylin-eosin slide preparations of breast cancer patients at Cibabat Hospital from 2022 to 2023 who met the inclusion criteria. The results showed that the majority of breast cancer patients at Cibabat Hospital had grade 3 (34.9%) and low TILs (65.1%). Statistical analysis showed no significant difference between TILs and breast cancer grade (p = 0.864- 0.864> 0.05). The conclusion of this study is that there is no association between TILs and histological grade of breast cancer in breast cancer patients at Cibabat Hospital.
Keywords: Breast cancer, Histological grading, TILs Tumour-Infiltrating Lymphocytes (TILs)
