Brown Algae Fucoidan: Impact on Osteoblast Cells During Osteogenesis Processes: A Narrative Review
Ardian Jayakusuma Amran1,2, Muhammad Ruslin2, Nurlindah Hamrun3, Muhammad Irfan Rasul2

1Departement of Oral Maxillofacial Surgery, Faculty of Dentistry, Universitas Muslim Indonesia, 90122, Makassar Indonesia
2Departement of Oral Maxillofacial Surgery, Faculty of Dentistry, Universitas Hasanuddin, 90122, Makassar Indonesia
3Departement of Oral Biology , Faculty of Dentistry, Universitas Hasanuddin, 90245, Makassar, Indonesia

Abstract

Introduction: Fucoidan is a brown algae-derived sulfated polysaccharide that has garnered interest due to its possible medicinal properties in a range of biological processes, particularly in the promotion of osteogenesis and angiogenesis. On the coast of South Sulawesi, brown algae Sargassum sp. is a nuisance problem for fishermen- yet, the fucoidan it contains can be used as an alternative to speed up the osteogenesis process in the treatment of alveolar bone loss.. These activities include reducing osteoclast activity and improving osteoblast differentiation. This narrative review investigates how osteoblast cells involved in angiogenesis and osteogenesis are affected by fucoidan derived from brown algae. The objective of this study is to provide insight into the possible therapeutic uses of fucoidan in treating alveolar bone resorption by analyzing the current literature.
Methode: This paper conducted a literature study using the PubMed database, Google Scholar, ResearchGate, and BMC databases to find keywords related to fucoidan, herbal medicine, angiogenesis, and osteogenesis.
Result: This narrative review uses data from PubMed, Google Scholar, and Researchgate to examine the possible advantages of fucoidan chemicals from brown algae, which can help with bone regeneration and angiogenesis by blocking the manufacture of osteogenic signals.
Conclusion: Osteoblast differentiation, osteoclast activity regulation, and osteogenic marker expression can all be enhanced by Sargassum sp. fucoidan. Fucoidan has the additional ability to hasten the osteogenesis process and encourage the growth of new bone tissue.

Keywords: Osteogenesis, Herbal Medicine,Fucoidan, Brown algae

Topic: Biomedical and Health Informatics