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Effect of Plectrantus amboinicus Leaf Nanoparticle Extract on The Growth Inhibition Zone of Treponema denticola, Fusobacterium nucleatum, and Enterococcus faecalisPlease Just Try to Submit This Sample Abstract Universitas Trisakti Fakultas Kedokteran Gigi Abstract The problems that quite high in Indonesia is dental and oral health problems. Treponema denticola, Fusobacterium nucleatum, and Enterococcus faecalis has known as pathological bacteria that caused periodontitis and caries. Plectrantus amboinicus is a plant that has long been used as medicine and food. Nanoparticles are particles with a size of 10 to 1000 nm. The macromolecular material contained has the potential to be used in medicine as a drug carrier, where the active compound has been dissolved, bound, and encapsulated. This study aims to determine the effect of P. amboinicus leaf nanoparticle extract on the growth inhibition zone of T. denticola, F.nucleatum, and E. faecalis. The P. amboinicus leaf extract ethyl acetate fraction of 50%, 75%, and 100% against the bacteria T. denticola, F. nucleatum, and E. faecalis which were incubated for 24 hours using the paper disc diffusion method with NaOCl and Chlorhexidine as positive controls. The phytochemical test P. amboinicus leaf extract ethyl acetate fraction results showed active compound of phenolics, flavonoids, steroids, terpenoids, saponins, tannins, and alkaloids. After 24 hours incubation, the diameter of inhibition zone obtained from P. amboinicus leaf extract ethyl acetate fraction increased with increasing concentration. Compared to positive controls this extract has lower inhibition zone. The ethyl acetate fraction of P. amboinicus leaf extract has inhibitory power in inhibiting the growth of T. denticola, F. nucleatum, and E. faecalis. Keywords: Enterococcus faecalis, Fusobacterium nucleatum, Inhibition zone, Nanoparticle extract, Plectrantus amboinicus, Treponema denticola Topic: Biology and Microbiology |
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