Caries Prevention With Hydroxyapatite In Children: A Systematic Review
Aninda Kartika Dewi,1* Meirina Gartika2

University of Padjadjaran

Abstract

Backgrounds: The annual increase of caries dental in children has made remineralizing agents a necessity in dental practice. Fluoride and hydroxyapatite are popular ingredients as remineralizing agent to prevent caries. Whilst fluoride is still more popular in dental practice, hydroxyapatite is known to have excellent remineralizing effect and biocompatibility. Objectives: This systematic review aims to determine the efficacy of hydroxyapatite-containing product compared to fluoride, as caries prevention in children. Methods: A systematic search with PICO frameworks and PRISMA guidelines was conducted on article published 10 years prior in PubMed, Scopus, and EBSCO databases, using keywords: hydroxyapatite, fluoride, caries, primary teeth. The PICO frameworks were ^P: In children, I: do oral care with hydroxyapatite-containing product, C: compared to fluoride, O: can prevent dental caries effectively?^. The inclusion criteria were clinical trial studies on human, caries prevention, children, and must include both hydroxyapatite and fluoride on all form of preparation. Risk of Bias 2.0 tool was used to assess the included studies. Results: 177 studies were retrieved, 171 studies were eliminated, and 6 studies met the inclusion criteria, covering 1751 patients. Using ROB tool, all included studies had low risk of bias. Vote counting direction of effect was used to analyze the data and determine the study outcome. The 5 included studies shown that hydroxyapatite containing product had the same efficacy as fluoride for caries preventing agent with its remineralization and antibacterial properties. Conclusions: There is good evidence that hydroxyapatite-containing product is as effective as fluoride for preventing caries in children.

Keywords: Hydroxyapatite, fluoride, pediatric, primary teeth, caries prevention.

Topic: Advance Materials for Health Applications