The Administration of 0.8% Hyaluronic Acid (HA) Gel Enhances The Capability of Bone Regeneration Following an Alveolar Bone Defect in Male Wistar Rats (Rattus norvegicus)
I Putu Gede Andyka Yasa1, I Made Jawi2. I Made Muliarta3

1Departemen of Biomedicine/Departement of Dental Radiology, Faculty of Dentistry, Mahasaraswati University Denpasar1
2Departement of Pharmacology, Faculty of Medicine, Udayana University2
3Departement of Physiology, Faculty of Medicine, Udayana University3

Abstract

Backgrounds: Alveolar bone damage, often resulting from periodontal diseases, deep tooth decay, or trauma, necessitates tooth extraction and initiates a complex bone healing process, frequently causing vertical and horizontal reduction of the alveolar bone. Objective: Study aims to ascertain the effects of administering 0.8% HA gel on bone regeneration following alveolar bone damage. Methods: Samples were divided into two groups: P1 (control) and P2 (treatment). In P1, only alveolar bone damage was induced, while in P2, HA was applied to the damaged alveolar bone. On the 7th day, the rats were euthanized, and their mandibles were collected for histological preparation and data analysis. Result: The mean value of osteoblasts showed a higher value in P2 than P1 group, that is 23.44-8.61 (P2) and 38.18-9.99 (P1). In contrast, the mean value of osteoclast showed a lower value in P2 than the P1 group, that is 1.27-0.57 (P2) 4.05-1.25 (P1). Conclusion: These results indicate a significant improvement in bone regeneration in the P2 group, demonstrating the positive effect of 0.8% HA gel on alveolar bone healing.

Keywords: Trauma, alveolar, HA gel

Topic: Biomolecular Chemistry