Antibacterial Potential of Ethanol Extract from Butterfly Pea Flower (Clitoria ternatea L.) Against Cutibacterium acnes in the Treatment of Acne Vulgaris
Joko Susanto,Gading Mangku Anugerah

Universitas Islam Bandung

Abstract

Acne vulgaris is a long-term inflammatory skin condition affecting the pilosebaceous units, primarily caused by the commensal bacterium Cutibacterium acnes. With a prevalence of approximately 9.4% in the global population, acne vulgaris ranks as the eighth most common skin disorder. Systemic oral antibiotic therapy is a crucial option for managing acne that is unresponsive to topical treatments. However, resistance of C. acnes to antibiotics poses a global challenge in the treatment of acne vulgaris.

This study aims to analyze the antibacterial activity of ethanol extract from butterfly pea flower (Clitoria ternatea L.) against C. acnes. Antibacterial testing was conducted by measuring the inhibition zones on agar medium at concentrations of 100%, 80%, 60%, 40%, and 20%, alongside determining the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) through dilution assays.

Results indicate that the ethanol extract of butterfly pea flower produced inhibition zones at concentrations of 80%, 60%, 40%, and 20%, with respective sizes of 14,45mm, 12,85mm, 11,82mm and 10,42mm. The dilution assays revealed that the MIC of the extract was 0.318%, while the MBC was found to be 1.25%.

Conclusion: The ethanol extract of Clitoria ternatea L. exhibits moderate antibacterial activity against C. acnes, suggesting its potential for development as an acne treatment formulation. Further research is necessary to elucidate the mechanisms of action and practical applications of this extract in the therapy of acne vulgaris.

Keywords: Herbal medicine

Topic: Herbal Medicine