The Self-nanoemulsifying (SNE) formula contains honey and clove oil as a wound healing therapy
Meta Maulida Damayanti, (a), Yuniarti (b), Caecielia Makaginsar c)

a) Pathology Anatomy Department, Faculty of Medicine, Universitas Islam Bandung, Bandung
b) Anatomy Department, Faculty of Medicine Universitas Islam Bandung, Bandung Indonesia
c) Department of Medical Education, Bioethics, Humanities and Islamic Insert, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia

Abstract

Phytochemicals derived from plants have been studied in medical practice and proven to have many benefits. Inflammatory skin diseases require safe, fast-acting, and good healing results for treatment materials. Pharmaceutical research is focused on designing new drug delivery systems to increase the bioavailability of drugs that are poorly soluble in water. The self-nanoemulsifying (SNE) drug delivery system, one of the lipid-based dosage forms, has proven promising in increasing solubility, permeability and avoiding first-pass metabolism by increasing lymphatic transport. The purpose of this study is to analyze the effectiveness of the use of Self-nanoemulsifying (SNE) containing honey and cloves (Syzygium aromaticum) as a skin wound healing therapy. This study is a form of effort to reveal scientific phenomena in medical science, so that it can be a reference and alternative material for the use of natural ingredients in inflammatory skin diseases. This research method uses a true-experiment design on 27 rats (Rattus novergicus) that were induced with wounds on the back area using a sharp knife and then divided into three treatment groups. The manufacture of SNE combination of honey and clove oil was carried out, and characterization and testing of candidate drug materials were carried out, then continued with application to experimental animals for four weeks with different observation times, namely days 7, 14, and 28. Histopathological examination of skin tissue was carried out to see the effectiveness of wound healing. The significance criteria used were p values <0.05. Data analysis used two-way Anova and comparison of each group using the chi-square test. The data obtained were analyzed using SPPS 26.0 software.

Keywords: Histopathology- skin inflammation- wound healing- self-nanoemusifying

Topic: Herbal Medicine