The Relationship Between Stroke Lesion Location and Cognitive Function Impairment in Ischemic Stroke Patients
Zahra Khairunnisa Karimah1, a), Fajar Handika1, b), Poca Anida1, c), Mochammad Faisal Afif Mochyadin2, d), Nugraha Sutadipura3, e), Alya Tursina2, f)

1Undergraduate Program, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia
2Department of Neurology, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia
3Department of Biochemistry, Nutrition, and Biomolecular, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia

Abstract

Stroke is the leading cause of death in Indonesia, accounting for 19.42% of all fatalities. According to data from the Basic Health Research (Riskesdas), the incidence of stroke in Indonesia increased by 56% from 2013 to 2018. In Indonesia, ischemic stroke accounts for a substantial 67% of all stroke cases. Poststroke cognitive impairment significantly contribute to morbidity and mortality after a stroke. There is a strong association between location of stroke lesions and cognitive function impairment. The purpose of this study was to study the relationship between the location of supratentorial, infratentorial and both ischemic stroke lesions with the MoCA-Ina score. This study was an observational study with a cross sectional study design. The study was conducted on 47 patients who were first diagnosed with a stroke ischemic from a head CT scan results in the Neurology Department of RSAU Dr. M. Salamun Bandung in August to October 2024. The research instrument is MoCA-Ina questionnaire. Version 17 of the social sciences statistics (SPSS) was used to process data. The results showed that among ischemic stroke patients, 31 out of 35 with supratentorial lesions (88.5%) experienced cognitive function impairment. Additionally, 9 out of 11 patients with both supratentorial and infratentorial lesions (81.8%) experienced cognitive function impairment. Notably, no patients with only infratentorial lesions experienced cognitive function impairment. The chi-square analysis of the data yielded a p-value of 0.046, indicating a significant relationship (p < 0.05). In conclusion, there was a relationship between stroke lesions location and cognitive function impairment in ischemic stroke patients. These findings highlight the importance of early detection and targeted interventions to manage cognitive impairment in stroke patients.

Keywords: Ischemic stroke, location of lesions stroke, cognitive function impairment

Topic: Degenerative Disease