Antihypercholesterolemic Activity of Ethanol Extract from Red Ginger (*Zingiber officinale var. rubrum Rhizoma) in Male Mice Model of Hypercholesterolemia
Gading Mangku Anugerah, Joko Susanto

Undergraduate Program, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia

Abstract

*Abstract*
Uncontrolled elevation of plasma cholesterol levels is a significant risk factor for various cardiovascular diseases, including hypertension, stroke, ischemic heart disease, and atherosclerosis. Furthermore, it increases the likelihood of chronic kidney injury, acute pancreatitis, and retinal lipemia. Statins are the conventional pharmacological agents employed in the management of hypercholesterolemia- however, their therapeutic application is frequently accompanied by adverse effects, including myopathy, liver dysfunction, renal insufficiency, diabetes, and ocular complications. This study aims to rigorously evaluate the antihypercholesterolemic efficacy of ethanol extract derived from red ginger (Zingiber officinale var. rubrum) in a hypercholesterolemic mouse model.

The investigation was designed as an in vivo experimental study utilizing a randomized allocation methodology involving 30 male Swiss Webster mice (Mus Musculus). Hypercholesterolemia was induced in the subjects through a high-fat dietary regimen. The administration of the ginger extract was conducted over a 14-day period, during which plasma cholesterol levels were quantified employing enzymatic assays and analyzed using spectrophotometric techniques. The data obtained were subjected to statistical analysis using ANOVA, adhering to a 95% confidence interval.

The results indicated that hypercholesterolemic mice receiving the ethanol extract of red ginger exhibited a statistically significant reduction in cholesterol levels compared to control groups that did not receive the extract.

*Conclusion*: The findings of this study suggest that ethanol extract from red ginger possesses substantial antihypercholesterolemic properties in a hypercholesterolemic mouse model, thereby underscoring its potential as an alternative therapeutic intervention for the management of hypercholesterolemia.

Keywords:

Topic: Herbal Medicine