Exploring the Potential of Plants as Medical Raw Material
Maya Tejasari (a), Listya Hanum Siswanti (a*)

a) Histology Department, Bandung Islamic University, Jalan Tamansari No.22, Bandung, Indonesia
*listya[at]unisba.ac.id

Abstract

Prolonged hyperglycemia can trigger tissue damage due to the formation of free radicals that affect vital organs, including the brain. Medicinal plant derivatives with hypoglycemic properties have been used in traditional medicine and traditional healing systems, i.e. kersen leaves (Muntingia calabura L.). This study aims to investigate the protective effects of water-extracted kersen leaves (Mutingia calabura L.) on brain histopathology in mice (Mus musculus) induced with alloxan, a compound known to cause hyperglycemia. This is an invivo study, used a total of 30 mice which were divided into 5 groups and given alloxan induction with a dose = 0.442 mg / 20gBW. The dose of cherry leaf extract was 200, 400, and 800 mg / grBW which was given once a day for 14 days. According to the study, giving kersen leaf extract to mice induced-alloxan considerably lessened brain damage. Histopathological study revealed less inflammation and fewer indications of brain cell degeneration. The kersen leaf extract also demonstrated efficacy in reducing blood glucose levels, indicating that it may have anti-hyperglycemic properties. Kersen leaf extract demonstrates significant protective effects against alloxan-induced brain injury in mice. These findings support the use of kersen leaves as a potential alternative medicine for liver protection and management of hyperglycemia

Keywords: Blood Glucose Levels, brain microstructure, hyperglicemia, medicinal plants

Topic: Herbal Medicine