Evaluating Risk Factors for Late-onset Neonatal Sepsis
Wedi Iskandar,1,2,a) Rizky Dwi Juniartho,2 YaniTriyani,2,3 Vidi Permatagalih2

1Department of Child Health, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia, 2Al Islam Hospital, Bandung, Indonesia, 3Department of Clinical Pathology, Faculty of Medicine, Universitas Islam Bandung, Bandung, Indonesia
a) Corresponding Author : wedi_iskandar[at]yahoo.com.

Abstract

Abstract. Late-onset neontal sepsis (LONS) encompasses sepsis presenting &#8805-72 hours after birth, is commonly attributed to hospital-acquired infections, and contributes significantly to morbidity and mortality among newborns. The study aims to determine the risk factors of LONS. The study design was case-control retrospective observational study, evaluated the medical records of neonates who were admitted to the neonatal care unit of Al Islam Hospital Bandung from January 2020 to December 2022. This study assessed the impact of independent variables- gestational age (GA), birth weight (BW), mechanical ventilator, invasive prosedure, total parenteral nutrition (TPN), length of stay. Chi-square to bivariate and logistic regression to multivariate analyses were utilized to examine the data. In total, 85 infants were included in the analysis, 29 cases of LONS (34.1%). In the bivariate analysis, the occurrence of LONS based on BW (<1,500 grams), GA (< 34 weeks), mechanical ventilator, invasive procedures, TPN, length of stay > 10 days were (P= 0.004- 95% CI 1.503 to 9.978- OR= 3.872), (P = 0.924- 95% CI 0.386 to 2.853- 1,050), (P= 0.079- 95% CI 0.836 to 12.030- OR= 3.171), (P= 0.171- 95% CI 0.756 to 4.717- OR= 1.888), (P= 0.005- 95% CI 1.513 to 20.782- OR= 5.608), (P= 0.038- 95%CI 1.031 to 9.356- OR= 3.106), respectively. On multivariate analysis, the risk factors were not significantly associated p >0.05, with Nagelkerke R2= 0.365. In conclusion, BW < 1,500 grams, TPN, and length of stay > 10 days had significant correlations with the occurrence of LONS, which increased by 36.5% with all variables, simultaneously.

Keywords: Late-onset neonatal sepsis, risk factors

Topic: Infection Disease