Changes in the Physico-chemical Properties of Nanostructured Lipid Carriers Caused by the Loading of Kaempferol
Nimatul Izza, Nozomi Watanabe, Hiroshi Umakoshi

1. Bioprocess Technology Study Program- Faculty of Agricultural Technology - Universitas Brawijaya

2. Division of Chemical Engineering, Graduate School of Engineering Science, Osaka University

email: izza_nimatul[at]ub.ac.id

Abstract

Products containing extracts of antioxidant compounds are prone to degradation. One strategy to overcome this problem is the use of lipid drug carriers, such as Nanostructured Lipid Carriers (NLCs). There have been many reports on the performance of NLCs for drug delivery systems, but no studies have looked at the effects of drug compounds on the physico-chemical properties of the lipid carrier from this perspective. This study aims to investigate the effect of kaempferol loading on the physico-chemical properties of NLC. The NLC used in this study consisted of 3 components: cetyl palmitate (CP), caprylic triglyceride (CaTG), and Tween 80 (T80). The research was carried out using several NLC compositions containing kaempferol compounds at certain concentrations. NLC was made by hot homogenization method. The physico-chemical properties of NLC such as particle size and distribution, zeta potential, fluidity, and polarity after loading were then observed. The results showed that kaempferol was not significantly affects the particle size, slightly increase the absolute zeta potential and polarity, and decrease the fluidity of the carriers. Knowledge on the changes in NLC properties due to the addition of kaempferol is useful for estimating the phase of NLC after loading. The phase is important in determining the appropriate drug delivery pathway for subsequent applications.

Keywords: Kaempferol- Antioxidant Compound- Drug Loading- DDS- NLC

Topic: Food biotechnology and bioprocess engineering